In the pathogenesis of osteoarthritis, a key role is played by the predominance of hyaluronic acid catabolism over its production and the reduced synthesis of collagen, a fundamental component of articular cartilage. Based on these insights, the formulation of the product was developed: hyaluronic acid is complemented by substances that support cartilage regeneration and ensure a long-lasting effect.

Hyaluronic Acid

• Improves the viscosity of synovial fluid
• Stimulates chondrocytes to increase endogenous synthesis of glycosaminoglycans
• Acts as an analgesic by coating nociceptors and reducing the production of nociceptive mediators
• Reduces the production of inflammatory mediators

Glycine

• An amino acid essential for collagen synthesis, representing every third amino acid residue in its structure
• Necessary for the formation of a stable triple-helix structure of collagen
• A component of the proteoglycan lubricin, important for joint lubrication and shock absorption
• Exhibits anti-inflammatory and antioxidant effects

Proline

• An amino acid essential for collagen synthesis in chondrocytes
• Important not only for collagen synthesis but also for other substances crucial to the physiological condition of connective tissue
• Has anti-inflammatory, analgesic, and immunomodulatory effects
• Supports the proliferation and differentiation of chondrocytes, contributing to the regulation of bone metabolism balance

N-acetylglucosamine

• Supports cartilage regeneration by activating the synthesis of proteoglycans and glycosaminoglycans in chondrocytes
• Inhibits matrix metalloproteinases
• Promotes the biosynthesis of hyaluronic acid
• Reduces the production of pro-inflammatory mediators

Monocomponent hyaluronic acid provides only short-term pain relief and functional improvement, whereas Algyl GGP, thanks to its composition, delivers a dual effect:

A laboratory study demonstrated that Algyl GGP is significantly more effective in treating knee osteoarthritis than monocomponent hyaluronic acid or saline solution, and leads to the regression of degenerative cartilage changes.⁶
In orthopedic practice, Algyl GGP has been tested on more than 200,000 patients with gonarthrosis and has proven to be effective and safe, with a long-lasting effect. A safety report confirms that no adverse effects—such as joint pain or swelling, injection site reactions, or other complications—were observed during application.

Fig. 1. Group with induced osteoarthritis after saline application: cartilage sections show irregularities and erosions caused by osteoarthritis.

Fig. 2. Group with induced osteoarthritis after hyaluronic acid application: cartilage surface is uneven, erosions extend into the subchondral bone, and inflammatory cells are present.

Fig. 3. Group with induced osteoarthritis after application of Algyl GGP: cartilage surface is smooth, indicating ongoing regeneration.